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PTAK-037

UCH-L3 Deubiquitinase Activity Assay Kit

For research use only. Not intended for any clinical use.

Cat. No. :   PTAK-037

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Cat. No. PTAK-037
Description The UCH-L3 Activity Assay Kit utilizes the ability of active human UCH-L3 deubiquitinase to cleave a synthetic DUB substrate to release a fluorophore, which can be easily quantified (Ex/Em = 360/460 nm) using a fluorescence microplate reader. This inhibitor screening kit thus allows rapid and reliable determination of the inhibitory effects of various compounds on UCH-L3 deubiquitinase and could be used to screen for novel inhibitors.
Component •UCH-L3 assay buffer
•UCH-L3 substrate
•UCH-L3 enzyme
•DUB inhibitor
•96-well plate
Applications Useful for detecting the activity of UCH-L3 and screening the UCH-L3 inhibito/activator.
Size 100 assays
Method Fluorescence
Caution Avoid freeze/thaw cycles
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What is UCH-L3?

A: UCH-L3 stands for Ubiquitin carboxyl-terminal hydrolase L3, which is a protein-coding gene.

What is the function of UCH-L3?

A: UCH-L3 is a deubiquitinating enzyme that plays a role in the removal of ubiquitin, a small protein that is attached to target proteins to regulate their degradation or localization within cells.

What is the role of UCH-L3 in cellular processes?

A: UCH-L3 is expressed in various tissues and is involved in several cellular processes, including protein degradation, signal transduction, and immune response.

What diseases are UCH-L3 associated with?

A: Dysregulation of UCH-L3 has been associated with certain neurodegenerative diseases, such as Parkinson's and Alzheimer's.

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