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rAAV-hSyn-DIO-N2cG-hGH

For research use only. Not intended for any clinical use.

Cat. No. :   RABVH-37

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Virus Particles Information

Cat. No. RABVH-37
Description Cre-dependent, neuron-specific AAV helper expressing the CVS-N2c rabies glycoprotein (N2cG) under hSyn. N2cG complements G-deleted rabies virus with higher transsynaptic efficiency and lower neuronal toxicity than standard RVG, and Cre dependence confines spread to the targeted neurons. Paired with a TVA helper, it supports efficient Cre-defined monosynaptic retrograde tracing.
Product Type Adeno-associated virus
Helper Function AAV helper expressing CVS-N2c rabies glycoprotein under Cre-dependent neuronal control
Applications
  1. Co-injection with TVA helper AAV and CVS-N2c-EnvA-ΔG RV for Cre-dependent monosynaptic retrograde tracing in neurons
  2. N2cG (CVS-N2c strain glycoprotein) provides higher transsynaptic efficiency and lower toxicity than SAD-B19 G
  3. hGH polyA for enhanced mRNA stability
  4. hSyn restricts to neurons; DIO restricts to Cre+ populations
  5. Mapping direct presynaptic inputs with reduced neurotoxicity (longer imaging windows)
Promoter Neuron-specific Promoter
Size Custom
Storage Store at -80℃. Avoid multiple freeze/thaw cycles.
Shipping Dry ice
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