Recombinant Human FLT3 (C-Fc)

Name: Recombinant Human FLT3 (C-Fc)
SKU: RP00141
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : RP00141 Tag : C-Fc

Expressed Region : Asn27-Asn541 Expression System : Human Cell

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Product Information

Gene Information

Cat. No.	RP00141
Description	The Recombinant Human FLT3 (C-Fc) is produced in our Human Cell expression system. The amino acid region expressed is Asn27-Asn541 with a Fc tag at the C terminus.
Species	Human
Tag	C-Fc
Mol Weight	85.3 KDa
Conjugate	Unconjugated
Format	Liquid
Expressed Region	Asn27-Asn541
Expression System	Human Cell
Formulation	Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.
Purity	>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Endotoxin Level	< 1 EU/µg of protein by LAL method
Storage	Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles.
Shipping	The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.

Target Gene	FLT3
Background	This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
Synonyms	Receptor-Type Tyrosine-Protein Kinase FLT3; FL Cytokine Receptor; Fetal Liver Kinase-2; FLK-2; Fms-Like Tyrosine Kinase 3; FLT-3; Stem Cell Tyrosine Kinase 1; STK-1; CD135; FLT3; FLK2; STK1

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