Human ATM Knockout Cell Line-A549

Name: Human ATM Knockout Cell Line-A549
SKU: CSC-RT2812
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RT2812

Target Gene : ATM Host Cell : A549

Size : >1x10⁶ cells/vial Validation : Sequencing

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RT2812
Description	This cell is a stable cell line with a homozygous knockout of human ATM using CRISPR/Cas9.
Target Gene	ATM
Host Cell	A549
Host Cell Species	Homo sapiens (Human)
Size	1 vial (>10^6 cell/vial)
Validation	Sequencing
Storage	Liquid Nitrogen
Shipping	Dry ice package

Revival

Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	ATM ataxia telangiectasia mutated [ Homo sapiens ]
Gene Symbol	ATM
Synonyms	AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1
Gene Description	ataxia telangiectasia mutated (includes complementation groups A, C and D)
GeneID	472
Uni ProtID	Q13315
mRNA Refseq	NM_000051.3
Protein Refseq	NP_000042.3
Chromosome Location	11q22-q23
Function	1-phosphatidylinositol-3-kinase activity; ATP binding; DNA binding; DNA-dependent protein kinase activity; histone serine kinase activity; protein N-terminus binding; protein binding; protein complex binding; protein dimerization activity; protein serine/threonine kinase activity;
Pathway	ATM mediated phosphorylation of repair proteins, organism-specific biosystem; ATM mediated response to DNA double-strand break, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Autodegradation of the E3 ubiquitin ligase COP1, organism-specific biosystem; BARD1 signaling events, organism-specific biosystem; BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem;
MIM	607585

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