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Panoply™ Human ATM Knockdown Stable Cell Line

Cat.No.
CSC-DC001114
Description
Creative Biogene's Knockdown Cell Lines are target specific shRNA lentivirus transduced cells. The percent knockdown levels range from 75-99% depending on the gene, as evaluated by RT-PCR. Cells are rigorously qualified and mycoplasma free.
Growth Properties
Adherent
Host Cell
HEK293 (Hela and other cell types are also available)
Morphology
Epithelial
Quality Control
Negative for bacteria, yeast, fungi and mycoplasma.
Shipping
Dry Ice
Size/Form
2 × 10^6 cells / vial
Species
Human
Storage
Liquid Nitrogen
Gene Information
Gene Symbol
ATM
Synonyms
AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1
Gene Description
ataxia telangiectasia mutated (includes complementation groups A, C and D)
Gene ID
UniProt ID
Q13315
mRNA Refseq
Protein Refseq
Chromosome Location
11q22-q23
Function
1-phosphatidylinositol-3-kinase activity; ATP binding; DNA binding; DNA-dependent protein kinase activity; histone serine kinase activity; protein N-terminus binding; protein binding; protein complex binding; protein dimerization activity; protein serine/threonine kinase activity;
Pathway
ATM mediated phosphorylation of repair proteins, organism-specific biosystem; ATM mediated response to DNA double-strand break, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Autodegradation of the E3 ubiquitin ligase COP1, organism-specific biosystem; BARD1 signaling events, organism-specific biosystem; BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem;
MIM

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