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Rat Atm ORF Clone(NM_001106821.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR373559

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Gene Information

Cat. No. CDCR373559
Product Type ORF Clone
Gene Abbr Atm
Species Rat
Tag C-terminal Myc-DDK
ORF Size 9195 bp
Vector pCMV6-Entry
Target Gene ATM
Background The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
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