Human ATM Knockdown Cell Line-HeLa

Name: Human ATM Knockdown Cell Line-HeLa
SKU: CSC-RK0028
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RK0028

Host Cell : HeLa Validation : Real-Time RCR

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Cell Line Information

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Gene Information

Cat. No.	CSC-RK0028
Target Gene	ATM
Abbr	HeLa-HuATM Knockdown
Alias	ATM, AT1, ATA, ATC, ATD, ATE
Host Cell	HeLa
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Morphology	Epithelial
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Shipping	Dry ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	ATM ataxia telangiectasia mutated [ Homo sapiens ]
Gene Symbol	ATM
Synonyms	AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1
Gene Description	ataxia telangiectasia mutated (includes complementation groups A, C and D)
GeneID	472
Uni ProtID	Q13315
mRNA Refseq	NM_000051.3
Protein Refseq	NP_000042.3
Chromosome Location	11q22-q23
Function	1-phosphatidylinositol-3-kinase activity; ATP binding; DNA binding; DNA-dependent protein kinase activity; histone serine kinase activity; protein N-terminus binding; protein binding; protein complex binding; protein dimerization activity; protein serine/threonine kinase activity;
Pathway	ATM mediated phosphorylation of repair proteins, organism-specific biosystem; ATM mediated response to DNA double-strand break, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Autodegradation of the E3 ubiquitin ligase COP1, organism-specific biosystem; BARD1 signaling events, organism-specific biosystem; BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem;
MIM	607585

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The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

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