shRNA set against Human ATM (NM_000051.3)

Name: shRNA set against Human ATM (NM_000051.3)
SKU: SHH242282
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : SHH242282

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Product Information

Gene Information

Cat. No.	SHH242282
Description	The SureSilencing trade; shRNA Plasmids are designed to specifically knock down the expression of individual genes by RNA interference under either transient (with GFP) or stable transfection (for hygromycin, neomycin or puromycin-resistance) conditions after performance of the appropriate enrichment or selection procedures, respectively. Each vector contains the shRNA under control of the U1 promoter and either the GFP gene, for the enrichment of transiently transfected cells, or the neomycin or puromycin resistance genes, for the selection of stably transfected cells.
Gene Abbr	ATM
Gene Name	ATM ataxia telangiectasia mutated [ Homo sapiens ]
Species	Human
Report Gene	GFP
Storage	The SureSilencing shRNA Plasmids are shipped on dry ice or cold packs. Store all tubes at -20°C.

Gene Name	ATM ataxia telangiectasia mutated [ Homo sapiens ]
Gene Symbol	ATM
Synonyms	AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1
Gene Description	ataxia telangiectasia mutated (includes complementation groups A, C and D)
GeneID	472
Uni ProtID	Q13315
mRNA Refseq	NM_000051.3
Protein Refseq	NP_000042.3
Chromosome Location	11q22-q23
Function	1-phosphatidylinositol-3-kinase activity; ATP binding; DNA binding; DNA-dependent protein kinase activity; histone serine kinase activity; protein N-terminus binding; protein binding; protein complex binding; protein dimerization activity; protein serine/threonine kinase activity;
Pathway	ATM mediated phosphorylation of repair proteins, organism-specific biosystem; ATM mediated response to DNA double-strand break, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Autodegradation of the E3 ubiquitin ligase COP1, organism-specific biosystem; BARD1 signaling events, organism-specific biosystem; BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem;
MIM	607585

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