ODN 2088

Name: ODN 2088
SKU: CGON-05
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CGON-05

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Product Information

Cat. No.	CGON-05
Description	CpG oligodeoxynucleotides (or CpG ODNs) are synthetic oligonucleotides that contain unmethylated CpG motifs. CpG ODN can bind to and activate a Toll-like receptor 9 (TLR9) and leading to strong immunostimulatory effects. So far 3 major classes of CpG ODNs have been identified, based on their structural and biological characteristics, and are designated Type A, Type B, and Type C. Type A ODNs, which feature a central palindromic CpG-containing phosphodiester (PO) structure followed by a phosphorothioate (PS) homopolymeric G-stretch, are robust inducers of interferon-α (IFN-α) production and dendritic cell maturation. Type B ODNs, in contrast, contain a full phosphorothioate backbone with one or more CpG dinucleotides. They strongly activate B cells but stimulate weakly IFN-α secretion. Type C ODNs, combine the properties of both Type A and B, and are characterized by their complete PS backbone and palindromic CpG-containing motifs. Type C ODNs induce strong IFN-α production from pDC and B cell stimulation. ODN 2088 can be used as TLR9-specific competitors, which may also affect TLR7 and TLR8 signaling.
Features	• Product format: Lyophilized product • Sequence: 5'-tcctggcggggaagt-3' (lower case letters are phosphorothioate) • Specificity: TLR9-specific competitors, which may also affect TLR7 and TLR8 signaling.
Storage	Store lyophilized product at -20°C. Upon reconstitution, aliquots should be stored at -20°C and are stable for 6 months. Avoid repeated freeze-thaw cycles.

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What are the differences compared to Type A and Type B?

A: C ODN combines the characteristics of both A-type and B-type ODNs, and is characterized by a complete PS backbone and a palindromic CpG motif.

Can I use this product for IFN-α-related experiments?

A: Yes, it is possible, because C-type ODN can induce strong IFN-α production by stimulating pDC and B cells.

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Customer Reviews

Virus model

The product can activate B cells and produce a large amount of IFN-α, which can establish a virus infection model.

United States

2022-06-16

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ODN 2088

Product Information

Q & A

Customer Reviews

What are the differences compared to Type A and Type B?

Can I use this product for IFN-α-related experiments?

Virus model

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