Monkey NCR1 Stable Cell Line - CHO-K1

Name: Monkey NCR1 Stable Cell Line - CHO-K1
SKU: CSC-RO0853
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RO0853

Host Cell : CHO-K1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Cat. No.	CSC-RO0853
Description	This cell line is engineered to stably overexpress monkey NCR1 (also named as NKp46).
Target Gene	NCR1
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Studying the interactions between immune cells and cancer cells 2. Studying the mechanisms of resistance to immune checkpoint blockade 3. High-throughput screening 4. Drug target validation
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival

Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

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Q & A

Customer Reviews

Customer Q&As

How is the stable expression of NCR1 achieved in the Monkey NCR1 Stable Cell Line - CHO-K1 through genetic engineering?

A: The stable expression of NCR1 in the Monkey NCR1 Stable Cell Line - CHO-K1 is achieved by introducing the NCR1 gene into CHO-K1 cells using genetic engineering techniques.

How can the role of NCR1 in viral infection processes be studied using the Monkey NCR1 Stable Cell Line - CHO-K1?

A: The role of NCR1 in viral infection processes can be investigated by modulating its expression levels in the Monkey NCR1 Stable Cell Line - CHO-K1. For example, RNA interference or CRISPR/Cas9 technology can be used to knock down or knockout the NCR1 gene, and observe changes in viral infection efficiency. In addition, NCR1 can be expressed in various types of viral infection models to study its functions in antiviral immunity.

What are the applications of the Monkey NCR1 Stable Cell Line - CHO-K1 in drug screening?

A: The Monkey NCR1 Stable Cell Line - CHO-K1 can be used for screening potential drugs targeting NCR1. For example, high-throughput screening methods can be employed to identify small molecule compounds that can inhibit NCR1 activity or expression. These compounds can then be further studied for their antiviral activities, providing a foundation for the development of novel antiviral drugs.

What are some unique features or characteristics of the Monkey NCR1 Stable Cell Line - CHO-K1 that differentiate it from other stable cell lines?

A: One unique feature of the Monkey NCR1 Stable Cell Line - CHO-K1 is its stable expression of the NCR1 gene, which allows for consistent and reproducible studies of NCR1-mediated immune responses. Additionally, this cell line may have specific post-translational modifications or glycosylation patterns associated with CHO-K1 cells, which could influence NCR1 function. Researchers should consider these characteristics when comparing results with other cell lines or primary cells expressing NCR1.

Can the Monkey NCR1 Stable Cell Line - CHO-K1 be used to model specific diseases or conditions in research?

A: Yes, the Monkey NCR1 Stable Cell Line - CHO-K1 can be used to model diseases or conditions related to NCR1 function. For example, researchers can use this cell line to investigate immune responses against cancer cells, as NCR1 is involved in the recognition and killing of tumor cells by NK cells. It can also be employed to study viral infections, as NCR1 is implicated in antiviral responses. By manipulating NCR1 expression and signaling in this cell line, researchers can gain insights into disease mechanisms and potential therapeutic interventions.

What are the primary applications of the Monkey NCR1 Stable Cell Line - CHO-K1 in research and biotechnology?

A: The Monkey NCR1 Stable Cell Line - CHO-K1 has several applications in research and biotechnology. It can be used to study the mechanisms of NCR1-mediated immune responses, including NK cell activation and cytotoxicity. Additionally, this cell line can be employed in drug screening assays to identify potential immunomodulatory compounds that target NCR1 signaling pathways. Furthermore, it may be used to develop therapeutic antibodies or biologics that modulate NCR1 function for cancer immunotherapy or other immune-related disorders.

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