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Cat.No. : CSC-RO0905 Host Cell: CHO-K1
| Cat. No. | CSC-RO0905 |
| Description | This cell line is engineered to stably overexpress human KLRD1 (also named as CD94). |
| Gene | KLRD1 |
| Gene Species | Homo sapiens (Human) |
| Host Cell | CHO-K1 |
| Host Cell Species | Cricetulus griseus (Chinese hamster) |
| Stability | Validated for at least 10 passages |
| Application | 1. Studying the interactions between immune cells and cancer cells 2. Studying the mechanisms of resistance to immune checkpoint blockade 3. High-throughput screening 4. Drug target validation |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
A: The Human KLRD1 Stable Cell Line - CHO-K1 expresses the human KLRD1 gene, which encodes the protein CD94, primarily active on the surface of Natural Killer (NK) cells. In the CHO-K1 cell line, the expression of the KLRD1 gene is maintained through stable transfection and selective culture media, ensuring its specificity and stability.
A: This cell line is highly adaptable as a tool for studying NK cell functions. It stably expresses CD94 protein, which is related to NK cell activity, and can be used to study the activation, inhibition mechanisms of NK cells, and their interactions with tumor cells.
A: Human KLRD1 Stable Cell Line - CHO-K1 has significant potential in drug screening, especially in finding drugs that can modulate NK cell activity. Its stable expression of proteins related to NK cell function makes it an ideal model for assessing how drugs affect NK cell activity.
A: The gene editing efficiency of this cell line can be assessed by monitoring changes in KLRD1 gene and protein expression through techniques such as quantitative PCR (qPCR) and Western blot. By comparing expression levels before and after editing, the editing efficiency can be effectively evaluated.
A: This cell line plays a key role in immunotherapy research. By simulating key characteristics of NK cells, it can be used to study the impact of different immunotherapy strategies, such as immune checkpoint inhibitors, on NK cell activity, thereby aiding in the development of new immunotherapy methods.
A: Human KLRD1 Stable Cell Line - CHO-K1 is very useful in studying signaling pathways related to NK cell activity. Researching the activation and inhibition mechanisms of KLRD1/CD94 can lead to a better understanding of how NK cells respond to immune challenges.
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