Human CD226 Stable Cell Line-CHO-S

Name: Human CD226 Stable Cell Line-CHO-S
SKU: CSC-RO1049
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RO1049

Host Cell : CHO-S Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RO1049
Description	CHO-S-CD226 cell line is engineered to stably overexpress human CD226.
Target Gene	CD226
Gene Species	Homo sapiens (Human)
Host Cell	CHO-S
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Studying the interactions between immune cells and cancer cells 2. Studying the mechanisms of resistance to immune checkpoint blockade 3. High-throughput screening 4. Drug target validation
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival

Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	Homo sapiens CD226 molecule DNA.
Gene Symbol	CD226
Synonyms	PTA1, DNAM1, DNAM-1, TLiSA1
mRNA Refseq	NM_006566.1

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Q & A

Customer Reviews

Customer Q&As

What is the specific function of Human CD226 Stable Cell Line-CHO-S, and how does it contribute to the study of immune cell interactions?

A: Human CD226 Stable Cell Line-CHO-S is a cell line engineered to express the CD226 antigen, which is a member of the immunoglobulin superfamily and plays a role in cell adhesion and immune cell activation. This cell line is particularly useful for studying the interactions between CD226 and its ligands, such as DNAM-1 (CD226), which is crucial for the activation of natural killer (NK) cells and T cells. It can be used to investigate the molecular mechanisms of immune cell activation and to develop therapeutic strategies for immune-related diseases.

How does the Human CD226 Stable Cell Line-CHO-S differ from other CHO cell lines in terms of its utility in biopharmaceutical production?

A: The Human CD226 Stable Cell Line-CHO-S is specifically engineered to express the CD226 protein, which is not typically found in standard CHO cell lines. This makes it a unique resource for the production of recombinant proteins or antibodies targeting CD226, which can be critical for the development of new therapeutics. Additionally, the stable expression of CD226 in this cell line allows for consistent and high-level production of the protein, which is essential for biopharmaceutical applications.

What are the key considerations for maintaining the stability of the Human CD226 Stable Cell Line-CHO-S in cell culture?

A: To maintain the stability of the Human CD226 Stable Cell Line-CHO-S, it is crucial to follow optimized culture conditions, including the use of appropriate growth media, temperature, and CO2 levels. Regular monitoring for mycoplasma contamination and periodic testing for the expression of CD226 are also necessary to ensure the cell line retains its intended characteristics. Additionally, cryopreservation and proper thawing procedures are essential to prevent loss of CD226 expression during cell passage.

How can the Human CD226 Stable Cell Line-CHO-S be utilized in the development of immunotherapies targeting CD226?

A: The Human CD226 Stable Cell Line-CHO-S can be used to screen for potential immunotherapeutic agents that modulate the activity of CD226. This can involve testing the effects of small molecules, antibodies, or other biologics on the expression and function of CD226. The cell line can also be used to generate CD226-specific antibodies for use in immunoassays or as therapeutic agents.

How does the Human CD226 Stable Cell Line-CHO-S contribute to the understanding of CD226's role in immune cell development and differentiation?

A: The Human CD226 Stable Cell Line-CHO-S provides a model system to study the role of CD226 in immune cell development and differentiation. By manipulating the expression levels of CD226 or its ligands, researchers can investigate the impact on cell proliferation, differentiation, and immune response. This can lead to insights into the molecular pathways regulated by CD226 and its implications for immune cell function.

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