DPP8 Activity Assay Kit

Name: DPP8 Activity Assay Kit
SKU: PTAK-024

For research use only. Not intended for any clinical use.

Cat.No.

PTAK-024

Description

The DPP8 Assay Kit is designed to measure DPP8 activity using purified DPP8 for screening and profiling applications. The key to the Fluorogenic DPP8 Assay Kit is the fluorogenic substrate. Using this kit, only one simple step on a microtiter plate is required for DPP8 reactions. The fluorometric substrate is incubated with a sample containing DPP8 enzyme to produce a fluorophore that can then be measured using a fluorescence reader.

Applications

Great for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.

Caution

Avoid freeze/thaw cycles

Component

•Active DPP8
•DPP8 fluorogenic substrate
•DPP8 assay buffer
•Fluorogenic AMC standard
•Microtiter plate

Method

Fluorescence

Size/Form

100 assays

Publications

Q & A

Customer Reviews

Customer Q&As

What is DPP8?

A: DPP8 refers to dipeptidyl peptidase 8, which is an enzyme that belongs to the prolyl oligopeptidase subfamily.

What is the role of DPP8 in biological processes?

A: DPP8 is mainly found in the cytoplasm of cells and has been implicated in various biological processes, including immune response modulation and cell signaling.

What is the role of DPP8 in multiple myeloma?

A: DPP8 expression was significantly increased in multiple myeloma cells compared to normal plasma cells. Inhibiting DPP8 activity led to decreased cell viability and increased apoptosis in multiple myeloma cells, suggesting that DPP8 may have anti-apoptotic properties and contribute to tumor survival.

Is DPP8 a therapeutic target for multiple myeloma?

A: Yes. The researchers found that DPP8 inhibition enhanced the cytotoxic effects of chemotherapy drugs in multiple myeloma cells, suggesting that targeting DPP8 could potentially improve treatment outcomes.

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