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Human PTH1R Stable Cell Line-HEK293T

Cat.No.
CSC-RG1744
Host Cell
HEK293T
Shipping
Dry ice
Source
HEK293T
Species
Human
Subgroup
Human
Background
The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis.
Gene Information
Gene Symbol
PTHR1
Synonyms
PFE; PTHR; PTHR1
Gene Description
parathyroid hormone receptor 1
Gene ID
UniProt ID
Q03431
mRNA Refseq
Protein Refseq
Chromosome Location
3p22-p21.1
Function
parathyroid hormone receptor activity; peptide hormone binding; protein self-association;
Pathway
Class B/2 (Secretin family receptors), organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, conserved biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem;
MIM

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