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Human PTAFR Stable Cell Line-CHO-K1

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Cat.No.
CSC-RG1700
Background
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants.
Host Cell
CHO-K1
Ship
Dry Ice
Antigen Gene Information
Official Symbol
PTAFR
Synonyms
PTAFR; PAFR; platelet-activating factor receptor; PAF-R
GeneID
MIM
UniProt ID
P25105
Chromosome Location
1p35-p34.3
Pathway
Calcium signaling pathway; Class A/1 (Rhodopsin-like receptors); Cytokine Signaling in Immune system; G alpha (q) signalling events; GPCR downstream signaling; GPCR ligand binding; GPCRs, Class A Rhodopsin-like;
Function
G-protein coupled receptor activity; lipopolysaccharide binding; lipopolysaccharide receptor activity; phospholipid binding; platelet activating factor receptor activity

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