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Human PROKR2 Stable Cell Line-CHO

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Cat.No.
CSC-RG0925
Background
Prokineticins are small proteins expressed in the GI tract and other tissues that regulate contraction of GI smooth muscle, angiogenesis and other responses. Two closely related receptors for prokineticins have been cloned, PKR1 and PKR2. PKR2 is expressed in ileocecum, in brain and in endocrine tissues. PKR2 is Gq coupled and has been shown to be activated by mamba intestinal toxin (MIT1). This PKR2-expressing cell line displays a very robust calcium response and is useful as a target for drug discovery.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Stability
At least 8 passages
Ship
Dry ice
Gene Information
Official Symbol
PROKR2
Synonyms
PROKR2; prokineticin receptor 2; G protein coupled receptor 73 like 1 , GPR73L1, KAL3, Kallmann syndrome 3 (autosomal dominant); dJ680N4.3; GPR73b; GPRg2; PKR2; PK-R2; G protein-coupled receptor 73-like 1; KAL3; GPR73L1;
Gene ID
MIM
UniProt ID
Q8NFJ6
Chromosome Location
20p12.3
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Other, organism-specific biosystem; Peptide ligand-binding receptors, organism-specific biosystem; Signal Transduction, organism-specific biosystem;
Function
G-protein coupled receptor activity; neuropeptide Y receptor activity; receptor activity; signal transducer activity;

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