Human PROKR2 Stable Cell Line-CHO-K1

Name: Human PROKR2 Stable Cell Line-CHO-K1
SKU: CSC-RG0925
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RG0925

Host Cell : CHO-K1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RG0925
Background	Prokineticins are small proteins expressed in the GI tract and other tissues that regulate contraction of GI smooth muscle, angiogenesis and other responses. Two closely related receptors for prokineticins have been cloned, PKR1 and PKR2. PKR2 is expressed in ileocecum, in brain and in endocrine tissues. PKR2 is Gq coupled and has been shown to be activated by mamba intestinal toxin (MIT1). This PKR2-expressing cell line displays a very robust calcium response and is useful as a target for drug discovery.
Target Gene	PROKR2
Gene Species	Homo sapiens (Human)
Abbr	CHO-HuPROKR2
Alias	PROKR2, GPR73L1, KAL3, dJ680N4.3, GPR73b, GPRg2, PKR2, PK-R2
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Research on the mechanisms of GPCR-related diseases
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent
Morphology	Epithelial-like

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	PROKR2 prokineticin receptor 2 [ Homo sapiens ]
Gene Symbol	PROKR2
Synonyms	HH3; KAL3; PKR2; GPRg2; GPR73b; GPR73L1; dJ680N4.3
Gene Description	prokineticin receptor 2
Gene ID	128674
Uni Prot ID	Q8NFJ6
m RNA Refseq	NM_144773.2
Protein Refseq	NP_658986.1
Chromosome Location	20p12.3
Function	neuropeptide Y receptor activity;
Pathway	Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Other, organism-specific biosystem; Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem; Peptide ligand-binding receptors, organism-specific biosystem;
MIM	607123

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