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Human MC5R Validated Stable Cell Line-CHO

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Cat.No.
CSC-RG1179
Background
The melanocortin system consists of five seven-transmembrane spanning G-protein coupled receptors, MC1-MC5. Among the five members of the melanocortin receptor family, MC2 and MC5 are expressed in peripheral tissues. The MC2 receptor (ACTH receptor) is almost exclusively expressed in the adrenal cortex whereas MC5 is expressed in several organs including the adrenal cortex. Studies have shown that targeted disruption of the MC5R gene produced mice with a severe defect in water repulsion and thermoregulation caused by decreased production of sebaceous lipids. In addition, MC5 is required for secretion from several exocrine glands, indicating that melanocortin peptides integrate the function of exocrine glands.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
MC5R
Synonyms
MC5R; melanocortin 5 receptor; melanocortin receptor 5; melanocortin-5 receptor; MC2;
Gene ID
MIM
UniProt ID
P33032
Chromosome Location
18p11.2
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem;
Function
G-protein coupled receptor activity; hormone binding; melanocortin receptor activity; protein binding; receptor activity; signal transducer activity;

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