Human KCNC2 Stable Cell Line-CHO-K1

Name: Human KCNC2 Stable Cell Line-CHO-K1
SKU: CSC-RI0038
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RI0038

Host Cell : CHO-K1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RI0038
Description	This cell line is engineered to overexpress human KCNC2.
Background	Kv3.2 channels are expressed in neurons known to fire at high frequency. Their biophysical properties could enable cells to generate the fast chains of action potentials involved in neuronal excitability. They are thought to play a role in the regulation of the human 24hr circadian rhythm, as they are highly expressed in the suprachiasmatic nucleus. Kv3.2 channels are also found in the insulin secreting beta-cells of the pancreas and their modulation could provide novel targets in the treatment of type-2 diabetes.
Target Gene	KCNC2
Gene Species	Homo sapiens (Human)
Abbr	CHO-HuKCNC2
Alias	KCNC2, KV3.2, MGC138196
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Channelopathies research
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent
Morphology	Epithelial-like

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	KCNC2 potassium voltage-gated channel, Shaw-related subfamily, member 2 [ Homo sapiens ]
Gene Symbol	KCNC2
Synonyms	KV3.2
Gene ID	268345
Uni Prot ID	J3KPP5
m RNA Refseq	NM_001260497.1
Protein Refseq	NP_001247426.1
Chromosome Location	12q14.1
Function	voltage-gated potassium channel activity;
Pathway	Integration of energy metabolism, organism-specific biosystem; Metabolism, organism-specific biosystem; Neuronal System, organism-specific biosystem; Potassium Channels, organism-specific biosystem; Regulation of Insulin Secretion, organism-specific biosystem; Regulation of Insulin Secretion by Glucagon-like Peptide-1, organism-specific biosystem; Voltage gated Potassium channels, organism-specific biosystem;
MIM	176256

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