Human KCNC1 Stable Cell Line-CHO-K1

Name: Human KCNC1 Stable Cell Line-CHO-K1
SKU: CSC-RI0037

Cat.No. : CSC-RI0037 Host Cell: CHO-K1

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Cell Line Information

Cell Culture Information

Safety and Packaging

Cat. No.	CSC-RI0037
Description	This cell line is engineered to overexpress human KCNC1.
Gene	KCNC1
Gene Species	Homo sapiens (Human)
Alias	KCNC1, Kv3.1, KV4, NGK2, KV3.1
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Morphology	Epithelial-like
Stability	Validated for at least 10 passages
Application	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Channelopathies research
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Shipping	Dry ice
Storage	Liquid nitrogen

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm² flask containing pre-warmed media.
Growth Properties	Adherent

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

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Kv3.1 mRNA is abundantly expressed in auditory brain stem neurons that are able to spike at high frequencies. It has a high threshold of activation and rapid activation/deactivation kinetics. Evidence for functional Kv3.1 activity in such neurons can be derived from the rapidly activating and deactivating potassium currents seen here, that activate at a high-voltage threshold similar to that of heterologously expressed Kv3.1. There are indications that the phosphorylation state in rat Kv3.1 may play a part in the ability of auditory neurons to adjust to the ambient acoustic environment. It is thought that Kv3.1 subunits are likely to form homomultimers in lymphocytes and therefore could be a target for the development of novel immunosuppresants.

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