Human KCNC1 Stable Cell Line-CHO-K1

Name: Human KCNC1 Stable Cell Line-CHO-K1
SKU: CSC-RI0037
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RI0037

Host Cell : CHO-K1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RI0037
Description	This cell line is engineered to overexpress human KCNC1.
Target Gene	KCNC1
Gene Species	Homo sapiens (Human)
Abbr	CHO-HuKCNC1
Alias	KCNC1, Kv3.1, KV4, NGK2, KV3.1
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Channelopathies research
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent
Morphology	Epithelial-like

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	KCNC1 potassium voltage-gated channel, Shaw-related subfamily, member 1 [ Homo sapiens ]
Gene Symbol	KCNC1
Synonyms	KV4; NGK2; KV3.1
Gene Description	potassium voltage-gated channel, Shaw-related subfamily, member 1
Gene ID	3746
Uni Prot ID	P48547
m RNA Refseq	NM_004976.4
Protein Refseq	NP_004967.1
Chromosome Location	11p15
Function	voltage-gated potassium channel activity;
Pathway	Neuronal System, organism-specific biosystem; Potassium Channels, organism-specific biosystem; Voltage gated Potassium channels, organism-specific biosystem;
MIM	176258

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Kv3.1 mRNA is abundantly expressed in auditory brain stem neurons that are able to spike at high frequencies. It has a high threshold of activation and rapid activation/deactivation kinetics. Evidence for functional Kv3.1 activity in such neurons can be derived from the rapidly activating and deactivating potassium currents seen here, that activate at a high-voltage threshold similar to that of heterologously expressed Kv3.1. There are indications that the phosphorylation state in rat Kv3.1 may play a part in the ability of auditory neurons to adjust to the ambient acoustic environment. It is thought that Kv3.1 subunits are likely to form homomultimers in lymphocytes and therefore could be a target for the development of novel immunosuppresants.

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