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Powerful Tn5 Transposase for DNA insertion and random library construction.
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Stable expression over 15 generations with rapid cell line development in just 3 months.
Supports adherent and suspension cell lines, offering MCB, WCB, and PCB establishment.
GMP mRNA Production
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High-throughput enzyme activity testing with proprietary datasets and deep learning models for standardized and precise enzyme engineering design.
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Leverage AI to uncover hidden high-potential small molecules, prioritize leads intelligently, and reduce costly trial-and-error in early drug discovery.
AI-Driven Protein Degrader Drug Development
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Use AI-guided design to optimize protein degraders, addressing design complexity and enhancing efficacy while shortening development timelines.
Cat.No. : CSC-RI0028 Host Cell: CHO-K1
| Cat. No. | CSC-RI0028 |
| Description | This cell line is engineered to overexpress human KCNA3. |
| Background | Kv1.3 is widely expressed throughout the CNS and in organs/cells involved with immune system such as spleen, tonsils, T-lymphocytes, B-lymphocytes and macrophages. Kv1.3 is involved in the regulation of the resting membrane potential and calcium signalling in lymphocytes and oligodendrocytes. This ion channel is a target for immunosuppressants and Kv1.3 inhibitors have been proven effective treatment in slowing the progression of multiple sclerosis. |
| Gene | KCNA3 |
| Gene Species | Homo sapiens (Human) |
| Alias | KCNA3, HLK3, HPCN3, Kv1.3, MK3, HGK5, PCN3, KV1.3, HUKIII |
| Host Cell | CHO-K1 |
| Host Cell Species | Cricetulus griseus (Chinese hamster) |
| Morphology | Epithelial-like |
| Stability | Validated for at least 10 passages |
| Application | 1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Channelopathies research |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Growth Properties | Adherent |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
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