Human KCNA3 Stable Cell Line-CHO-K1

Name: Human KCNA3 Stable Cell Line-CHO-K1
SKU: CSC-RI0028
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RI0028

Host Cell : CHO-K1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RI0028
Description	This cell line is engineered to overexpress human KCNA3.
Background	Kv1.3 is widely expressed throughout the CNS and in organs/cells involved with immune system such as spleen, tonsils, T-lymphocytes, B-lymphocytes and macrophages. Kv1.3 is involved in the regulation of the resting membrane potential and calcium signalling in lymphocytes and oligodendrocytes. This ion channel is a target for immunosuppressants and Kv1.3 inhibitors have been proven effective treatment in slowing the progression of multiple sclerosis.
Target Gene	KCNA3
Gene Species	Homo sapiens (Human)
Abbr	CHO-HuKCNA3
Alias	KCNA3, HLK3, HPCN3, Kv1.3, MK3, HGK5, PCN3, KV1.3, HUKIII
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Channelopathies research
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent
Morphology	Epithelial-like

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	KCNA3 potassium voltage-gated channel, shaker-related subfamily, member 3 [ Homo sapiens ]
Gene Symbol	KCNA3
Synonyms	MK3; HGK5; HLK3; PCN3; HPCN3; KV1.3; HUKIII
Gene Description	potassium voltage-gated channel, shaker-related subfamily, member 3
GeneID	3738
Uni ProtID	P22001
mRNA Refseq	NM_002232.3
Protein Refseq	NP_002223.3
Chromosome Location	1p13.3
Function	delayed rectifier potassium channel activity; outward rectifier potassium channel activity; voltage-gated ion channel activity;
Pathway	Neuronal System, organism-specific biosystem; Potassium Channels, organism-specific biosystem; Voltage gated Potassium channels, organism-specific biosystem;
MIM	176263

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