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Cat.No. : CSC-RG0061 Host Cell: CHO-K1
| Cat. No. | CSC-RG0061 |
| Background | Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Gene | HRH2 |
| Gene Species | Homo sapiens (Human) |
| Alias | HRH2, HH2R, H2R |
| Host Cell | CHO-K1 |
| Species | Cricetulus griseus (Chinese hamster) |
| Morphology | Epithelial-like |
| Stability | Validated for at least 10 passages |
| Application | 1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Research on the mechanisms of GPCR-related diseases |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Growth Properties | Adherent |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
A: The Human HRH2 Stable Cell Line-CHO (Chinese Hamster Ovary) is predominantly used for studying the function and pharmacology of the human histamine H2 receptor (HRH2). This cell line enables researchers to screen potential drugs that target the H2 receptor, which is involved in various physiological processes such as gastric acid secretion and immune response modulation.
A: This cell line, engineered to stably express the human H2 histamine receptor, allows for the investigation of receptor activation, downstream signaling cascades, and the effects of ligands on these pathways. It provides a model system to study the molecular mechanisms of H2 receptor signaling, which can lead to insights into diseases where the H2 receptor plays a role.
A: This cell line serves as a platform for high-throughput screening of compounds that can bind to and inhibit the H2 receptor. By measuring the receptor's activity in response to these compounds, researchers can identify potential H2 receptor antagonists, which could be further developed into therapeutic agents for conditions such as peptic ulcer disease and allergy.
A: By labeling the HRH2 receptor with fluorescent tags, researchers can use the Human HRH2 Stable Cell Line-CHO to visualize and track the receptor's movement within the cell, including its trafficking to the cell membrane, internalization upon ligand binding, and subsequent recycling or degradation.
A: Functional validation typically involves assays such as ligand binding assays, cAMP accumulation assays, and calcium flux assays to confirm that the HRH2 receptor in the cell line responds appropriately to agonists and antagonists, mimicking the receptor's behavior in vivo.
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