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Human HCRTR2 Stable Cell Line-CHO

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Cat.No.
CSC-RG0909
Background
The orexins (orexina-A and orexin-b) have a range of physiological functions including the control of feeding and energy metabolism, modulation of neuroendocrine function, and regulation of the sleep-wake cycle. The two orexin receptor subtypes OX1 and OX2 both mediate the action of orexin-A and orexin-B and couple efficiently through Gq/11 to activate phospholipase C and lead to elevation of intracellular calcium, though orexin-A is equipotent at OX1 and OX2, whilst orexin-B displays a moderate selectivity for OX2.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
HCRTR2
Synonyms
HCRTR2; hypocretin (orexin) receptor 2; orexin receptor type 2; OX2R; ox2-R; ox-2-R; hypocretin receptor type 2;
Gene ID
MIM
UniProt ID
O43614
Chromosome Location
6p11-q11
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem;
Function
G-protein coupled receptor activity; neuropeptide receptor activity; orexin receptor activity; peptide hormone binding; receptor activity; signal transducer activity;

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