Human FFAR1 Stable Cell Line-CHO-K1

Name: Human FFAR1 Stable Cell Line-CHO-K1
SKU: CSC-RG0858
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RG0858

Host Cell : CHO-K1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RG0858
Background	GPR40 is a member of the free fatty acid G protein coupled receptor family and is activated by saturated and unsaturated carboxylic acids with carbon chain lengths greater than six. Expression analysis shows that GPR40 is specifically expressed in brain and in insulin-producing beta cells in the pancreas. Activation of GPR40 by long-chain fatty acids has been shown to amplify glucose-stimulated insulin secretion, suggesting that GPR40 may represent an important target for drugs that regulate diabetes. GPR40 has also been shown to be overexpressed in breast cancer cells, where it may regulate cell growth.
Target Gene	FFAR1
Gene Species	Homo sapiens (Human)
Abbr	CHO-HuFFAR1
Alias	FFAR1, GPR40, FFA1R, GPCR40
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Research on the mechanisms of GPCR-related diseases
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent
Morphology	Epithelial-like

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	FFAR1 free fatty acid receptor 1 [ Homo sapiens ]
Gene Symbol	FFAR1
Synonyms	FFAR1; free fatty acid receptor 1; G protein coupled receptor 40 , GPR40; FFA1R; G protein-coupled receptor 40; G-protein coupled receptor 40; GPR40; GPCR40;
GeneID	2864
Uni ProtID	O14842
mRNA Refseq	BC120944
Chromosome Location	19q13.1
Function	G-protein coupled receptor activity; fatty acid binding; guanyl-nucleotide exchange factor activity; receptor activity; signal transducer activity;
Pathway	Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Free fatty acid receptors, organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Incretin Synthesis, Secretion, and Inactivation, organism-specific biosystem;
MIM	603820

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