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Human CHRM4/Rat Kcnj3/Mouse Kcnj6 Stable Cell Line-HEK293

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Cat.No.
CSC-RG0879
Background
Stimulation of Gi-coupled receptors in heart and brain activates G-protein-gated inward rectifier K+ channels (GIRK) via Gbetagamma (Dascal, N. 2001). This activity can be detected using a GIRK-mediated thallium flux assay described by Niswender et al., 2008. This assay is compatible with HTS and represents a novel and a sensitive assay for detecting Gi/o -coupled GPCRs.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293
Ship
Dry ice
Gene Information
Official Symbol
Kcnj6
Synonyms
KCNJ6; potassium inwardly-rectifying channel, subfamily J, member 6; G protein-activated inward rectifier potassium channel 2; GIRK-2; inward rectifier K(+) channel Kir3.2; potassium inwardly-rectifying channel J6; potassium channel, inwardly rectifying subfamily J member 6; wv; BIR1; GIRK2; KATP2; KCNJ7; Kir3.2; weaver;
Gene ID
Pathway
Activation of G protein gated Potassium channels, organism-specific biosystem; Activation of GABAB receptors, organism-specific biosystem; Cholinergic synapse, organism-specific biosystem; Dopaminergic synapse, organism-specific biosystem; Dopaminergic synapse, conserved biosystem; G protein gated Potassium channels, organism-specific biosystem; GABA B receptor activation, organism-specific biosystem;
Function
G-protein activated inward rectifier potassium channel activity; G-protein alpha-subunit binding; inward rectifier potassium channel activity; ion channel activity; voltage-gated ion channel activity;

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