Human ADRA1B Stable Cell Line-U2OS

Name: Human ADRA1B Stable Cell Line-U2OS
SKU: CSC-RG0019
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RG0019

Host Cell : U2OS Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RG0019
Background	Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins. The alpha-adrenergic receptor (AR) subtypes (alpha(1a), alpha(1b), and alpha(1d)) mediate some physiological effects of epinephrine and norepinephrine. The alpha1-AR subtypes are expressed in several organs like brain or heart in which they modulate a diversity of functional effects such as modulation of neurotransmission, vasoconstriction, etc.
Target Gene	ADRA1B
Gene Species	Homo sapiens (Human)
Abbr	U2OS-HuADRA1B
Alias	ADRA1B, ADRA1, ALPHA1BAR
Host Cell	U2OS
Host Cell Species	Homo sapiens (Human)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Research on the mechanisms of GPCR-related diseases
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	ADRA1B adrenoceptor alpha 1B [ Homo sapiens ]
Gene Symbol	ADRA1B
Synonyms	ADRA1; ALPHA1BAR
Gene Description	adrenergic, alpha-1B-, receptor
GeneID	147
Uni ProtID	P35368
mRNA Refseq	NM_000679.3
Protein Refseq	NP_000670.1
Chromosome Location	5q33.3
Function	alpha1-adrenergic receptor activity; protein heterodimerization activity;
Pathway	AMPK signaling, organism-specific biosystem; Adrenoceptors, organism-specific biosystem; Amine ligand-binding receptors, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem;
MIM	104220

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What is the role of the Human ADRA1B Stable Cell Line-U2OS in studying the impact of ADRA1B gene mutations on cellular function?

A: The Human ADRA1B Stable Cell Line-U2OS allows scientists to investigate how ADRA1B gene mutations affect cellular function. By comparing the expression and function of wild-type and mutant ADRA1B, researchers can better understand how these mutations lead to changes in cellular signal transduction, which is significant for the study of genetic cardiovascular diseases.

How is the Human ADRA1B Stable Cell Line-U2OS applied in studying the role of ADRA1B in stress responses?

A: The Human ADRA1B Stable Cell Line-U2OS can be used to study the role of ADRA1B in stress responses, particularly in dealing with environmental stressors and physiological challenges. This cell line helps scientists understand the molecular mechanisms of ADRA1B in regulating stress responses, which has potential value for developing treatment strategies for stress-related diseases.

How is the Human ADRA1B Stable Cell Line-U2OS applied in studying the role of ADRA1B in cardiovascular diseases?

A: The Human ADRA1B Stable Cell Line-U2OS provides an experimental model for studying the role of ADRA1B in cardiovascular diseases. Through this cell line, scientists can investigate how ADRA1B affects the function of the heart and blood vessels, which is crucial for understanding the pathogenesis of cardiovascular diseases and developing new treatment strategies.

How is the Human ADRA1B Stable Cell Line-U2OS applied in studying the role of ADRA1B in emotional regulation?

A: The Human ADRA1B Stable Cell Line-U2OS can be used to study the role of ADRA1B in emotional regulation, particularly in the limbic system of the brain. This cell line helps scientists explore how ADRA1B receptors influence emotional states, which is valuable for understanding the mechanisms of mood-related disorders such as depression and anxiety.

What is the role of the Human ADRA1B Stable Cell Line-U2OS in studying adrenergic receptor signaling?

A: The Human ADRA1B Stable Cell Line-U2OS, established by stably expressing the human α1B adrenergic receptor (ADRA1B) in U2OS cells, is crucial for studying how adrenergic receptors regulate intracellular signaling and physiological responses. It aids scientists in understanding the role of ADRA1B in the cardiovascular system, nervous system, and stress responses.

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