shRNA set against Human MRE11A (NM_005590.3)

Name: shRNA set against Human MRE11A (NM_005590.3)
SKU: SHH344216
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : SHH344216

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Product Information

Gene Information

Cat. No.	SHH344216
Description	The SureSilencing trade; shRNA Plasmids are designed to specifically knock down the expression of individual genes by RNA interference under either transient (with GFP) or stable transfection (for hygromycin, neomycin or puromycin-resistance) conditions after performance of the appropriate enrichment or selection procedures, respectively. Each vector contains the shRNA under control of the U1 promoter and either the GFP gene, for the enrichment of transiently transfected cells, or the neomycin or puromycin resistance genes, for the selection of stably transfected cells.
Gene Abbr	MRE11A
Gene Name	MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) [ Homo sapiens ]
Species	Human
Report Gene	GFP
Storage	The SureSilencing shRNA Plasmids are shipped on dry ice or cold packs. Store all tubes at -20°C.

Gene Name	MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) [ Homo sapiens ]
Gene Symbol	MRE11A
Synonyms	ATLD; HNGS1; MRE11; MRE11B
Gene Description	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Gene ID	17535
Uni Prot ID	P49959
m RNA Refseq	NM_005591.3
Protein Refseq	NP_005582.1
Chromosome Location	11q21
Function	3-5 exonuclease activity; contributes_to ATP-dependent DNA helicase activity; contributes_to DNA binding; double-stranded DNA binding; endodeoxyribonuclease activity; manganese ion binding; nuclease activity; protein C-terminus binding; protein binding; single-stranded DNA specific endodeoxyribonuclease activity;
Pathway	Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks, organism-specific biosystem; BARD1 signaling events, organism-specific biosystem; BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem; DNA Repair, organism-specific biosystem; DNA damage response, organism-specific biosystem; Double-Strand Break Repair, organism-specific biosystem; Homologous Recombination Repair, organism-specific biosystem;
MIM	600814

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