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Human MRE11 Knockdown Cell Line-HeLa

Cat.No.
CSC-RK0010
Human MRE11 Knockdown Cell Line-HeLa
Abbr
HeLa-HuMRE11 Knockdown
Alias
MRE11A,ATLD,HNGS1,MRE11,MRE11B,
Growth Properties
Adherent
Host Cell
HeLa
Morphology
Epithelial
Shipping
Dry ice
Species
Human
Background
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3 to 5 exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3 to 5 exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

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