Transfected Stable Cell Lines
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Cat. No. : CDCR378965
| Cat. No. | CDCR378965 |
| Product Type | ORF Clone |
| Gene Abbr | Mre11a |
| Species | Rat |
| Tag | C-terminal Myc-DDK |
| ORF Size | 2121 bp |
| Vector | pCMV6-Entry |
| Target Gene | Mre11a |
| Background | Enables nuclease activity. Involved in DNA strand resection involved in replication fork processing; chromosome organization; and double-strand break repair via homologous recombination. Acts upstream of or within several processes, including double-strand break repair; homologous chromosome pairing at meiosis; and mitotic DNA damage checkpoint signaling. Located in PML body. Part of Mre11 complex. Colocalizes with chromosome, telomeric region. Is expressed in cerebral cortex and telencephalon. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome; ataxia-telangiectasia-like disorder-1; endometrial cancer; gastrointestinal system cancer (multiple); and urinary bladder cancer. Orthologous to human MRE11 (MRE11 homolog, double strand break repair nuclease). [provided by Alliance of Genome Resources, Feb 2025] |
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