PTP1B Assay Kit

Name: PTP1B Assay Kit
SKU: PAK-006
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : PAK-006

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Product Information

Cat. No.	PAK-006
Description	The PTP1B Assay Kit is a colorimetric, non-radioactive assay designed to measure the phosphatase activity of purified PTP1B. This 96-well assay is useful for screening inhibitors and modulators of PTP1B activity.
Component	•PTP1B enzyme •PTP1B assay buffer •PTP1B substrate •PTP1B inhibitor •Phosphate standard •96-well microplate
Applications	Useful for detecting the activity of PTP1B and screening the PTP1B inhibitors/modulators.
Size	100 assays
Method	Colorimetric
Caution	Avoid freeze/thaw cycles

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What is PTP1B?

A: PTP1B, also known as protein tyrosine phosphatase 1B, is an enzyme that belongs to the protein tyrosine phosphatase family. It is encoded by the PTPN1 gene in humans.

What is the role of PTP1B in signaling pathways?

A: PTP1B plays a crucial role in regulating the signaling pathways involved in cell growth, metabolism, and insulin signaling.

What is the structure of PTP1B?

A: The first crystal structure of the PTP1B catalytic domain reveals that the catalytic site resides within a deep cleft in the protein formed by three loops, including the WPD loop with Asp181 residue, a pTyr loop with Tyr46 residue, and a Q loop with the Gln262 residue.

What diseases are PTP1B associated with?

A: PTP1B has been implicated in several diseases, including obesity, diabetes, and cancer, making it an important target for therapeutic interventions.

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