Mouse Trem2-Tyrobp Stable Cell Line - HEK293T

Trem2 (myeloid cell-expressed triggering receptor 2) and Tyrobp (TYRO protein tyrosine kinase-binding protein) are two important proteins involved in the brain's immune response. Both proteins are most prominently expressed in microglia, the main immune cells of the central nervous system. Trem2 is a receptor that initiates protective microglial responses to injury, infection, and other threats. When Trem2 binds to its ligand, it triggers intracellular signaling pathways that lead to microglial activation, proliferation, and survival. Tyrobp, also known as DAP12, functionally interacts with Trem2 and plays a crucial role in immune responses. Tyrobp acts as an adapter molecule that transduces signals from Trem2 into the cell interior. Upon activation of Trem2, Tyrobp is phosphorylated and downstream signaling processes are initiated, leading to microglial activation. Mouse Trem2-Tyrobp Stable Cell Line - HEK293T is a scientifically engineered cell line in which human embryonic kidney cells (HEK293T) are stably modified to express mouse Trem2 and Tyrobp. This cell line can be effectively used for various research or drug discovery purposes. The expression and interaction between Trem2 and Tyrobp can be further examined in this cell line, providing important insights into their function and involvement in health and disease, particularly in age-related neurodegenerative diseases such as Alzheimer's disease.