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Cat.No. : CSC-RO0537 Host Cell: HEK293T
| Cat. No. | CSC-RO0537 |
| Description | This cell line is derived from HEK293T and is engineered to stably overexpress Cyno TNFRSF17. |
| Gene | TNFRSF17 |
| Host Cell | HEK293T |
| Host Cell Species | Homo sapiens (Human) |
| Stability | Validated for at least 10 passages |
| Application | 1. Studying the interactions between immune cells and cancer cells 2. Studying the mechanisms of resistance to immune checkpoint blockade 3. High-throughput screening 4. Drug target validation |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Growth Properties | Cells are cultured as a monolayer at 37°C in a humidified atmosphere with 5% CO2. Split at 80-90% confluence, approximately 1:3-1:6. |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
A: Monkey TNFRSF17 Stable Cell Line - HEK293T has broad prospects in tumor immunotherapy research. The expression of TNFRSF17 in the tumor microenvironment is related to immune escape mechanisms, and this cell line can be used to study the role of TNFRSF17 in the interaction between tumor cells and the immune system, providing a basis for developing novel immunotherapeutic strategies.
A: When conducting gene expression analysis, it is important to choose appropriate detection methods, such as real-time quantitative PCR or RNA sequencing, and to strictly control experimental conditions. Particularly, attention should be paid to the cellular responses under TNFRSF17 stimulation, including changes in gene expression and activation of signaling pathways.
A: Monkey TNFRSF17 Stable Cell Line - HEK293T can play a role in studying chronic inflammatory diseases, especially in researching TNFRSF17-related inflammatory pathways and cytokine expression. This cell line can help reveal the mechanisms of TNFRSF17 in chronic inflammation, providing valuable insights for developing new treatments for these diseases.
A: For drug screening, optimizing the culture conditions of Monkey TNFRSF17 Stable Cell Line - HEK293T to ensure stable expression and functionality of TNFRSF17 is crucial. Additionally, employing high-throughput screening techniques and precise cell viability assays, such as cell proliferation and apoptosis tests, is essential to ensure the efficiency and accuracy of drug screening.
A: Monkey TNFRSF17 Stable Cell Line - HEK293T, with its stable expression of monkey TNFRSF17 (Tumor Necrosis Factor Receptor Superfamily Member 17), holds significant potential in multiple myeloma research. TNFRSF17 plays a key role in the survival and proliferation of multiple myeloma cells, and this cell line can be used to study the biological functions of TNFRSF17 and develop therapeutic strategies targeting TNFRSF17.
A: By using Monkey TNFRSF17 Stable Cell Line - HEK293T, the role of TNFRSF17 in immune cell activation and regulation can be studied through techniques like co-immunoprecipitation, flow cytometry, and cytokine analysis. This will help in understanding the mechanisms of TNFRSF17 in immune responses, particularly in B-cell activation and differentiation.
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