Human KLRD1/KLRC1 Stable Cell Line - CT26

Name: Human KLRD1/KLRC1 Stable Cell Line - CT26
SKU: CSC-RO0904
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RO0904

Host Cell : CT26 Size : >1x10⁶ frozen cells/vial

Inquire for Price

Cell Line Information

Cell Culture Information

Safety and Packaging

Cat. No.	CSC-RO0904
Description	This cell line is engineered to stably overexpress human KLRD1/KLRC1 (also named as CD94-NKG2A).
Target Gene	KLRD1/KLRC1
Gene Species	Homo sapiens (Human)
Host Cell	CT26
Host Cell Species	Mus musculus (Mouse)
Applications	1. Studying the interactions between immune cells and cancer cells 2. Studying the mechanisms of resistance to immune checkpoint blockade 3. High-throughput screening 4. Drug target validation
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival

Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Quick Inquiry

Q & A

Customer Reviews

Customer Q&As

What is the purpose of establishing the Human KLRD1/KLRC1 Stable Cell Line - CT26?

A: The Human KLRD1/KLRC1 Stable Cell Line - CT26 was established for researching the functions of human natural killer (NK) cell receptors KLRD1 and KLRC1. These receptors play a critical role in the immune system, particularly in identifying and eliminating infected or mutated cells. Using this cell line, scientists can gain deeper insights into how these receptors affect NK cell activity and immune response.

What specific genetic modifications are included in the Human KLRD1/KLRC1 Stable Cell Line - CT26?

A: In the Human KLRD1/KLRC1 Stable Cell Line - CT26, human NK cell surface receptors KLRD1 (CD94) and KLRC1 (NKG2A) are stably expressed through genetic engineering techniques. This modification allows the cells to simulate certain functions of NK cells, especially in interacting with their ligands, such as HLA-E.

How can Human KLRD1/KLRC1 Stable Cell Line - CT26 help understand tumor immune evasion mechanisms?

A: Studying the interactions between Human KLRD1/KLRC1 Stable Cell Line - CT26 and tumor cells can reveal how tumor cells evade NK cell-mediated immune surveillance by altering HLA-E expression. Additionally, this cell line can be used to study how tumor cells resist NK cell attacks by affecting the signaling of KLRD1 and KLRC1 receptors.

What is the impact of co-expression of KLRD1 and KLRC1 receptors on the functionality of the Human KLRD1/KLRC1 Stable Cell Line - CT26?

A: The co-expression of KLRD1 and KLRC1 receptors plays a key role in regulating NK cell activity. In Human KLRD1/KLRC1 Stable Cell Line - CT26, this co-expression might enhance the cell's responsiveness to specific signals, thereby more accurately simulating NK cell immune regulation functions.

What is the potential application of Human KLRD1/KLRC1 Stable Cell Line - CT26 in immune therapy research?

A: Due to its ability to simulate key functions of NK cells in immune responses, this cell line has significant application potential in the field of immune therapy. Especially in developing new therapies or vaccines targeting NK cell receptors, it provides a valuable research tool.

What role does Human KLRD1/KLRC1 Stable Cell Line - CT26 play in disease model research?

A: This cell line can serve as a model to help researchers simulate and understand the role of NK cells in various diseases (such as cancer, autoimmune diseases). Using this cell line in disease models allows scientists to explore how NK cells influence the development and progression of diseases.

Ask a Question

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

Question *

Name

Country *

Email *

Write a Review

Write a review of your use of Biogene products and services in your research. Your review can help your fellow researchers make informed purchasing decisions.

Product Name *

Catalog Name *

Rating

Needs improvement

Satisfaction

General satisfaction

Very satisfaction

Product Review Title *

Summary *