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Cat.No. : CSC-RO0481 Host Cell: CHO-K1
| Cat. No. | CSC-RO0481 |
| Description | This cell line is derived from CHO-K1 and is engineered to stably overexpress Human CD33. |
| Gene | CD33 |
| Gene Species | Homo sapiens (Human) |
| Host Cell | CHO-K1 |
| Host Cell Species | Cricetulus griseus (Chinese hamster) |
| Stability | Validated for at least 10 passages |
| Application | 1. Studying the interactions between immune cells and cancer cells 2. Studying the mechanisms of resistance to immune checkpoint blockade 3. High-throughput screening 4. Drug target validation |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
A: The Human CD33 Stable Cell Line - CHO-K1 cell line, by stably expressing CD33, a surface marker of myeloid cells, provides a model system for studying the development and differentiation of myeloid cells. This cell line can help scientists understand the function of CD33 during myeloid cell maturation and how it affects cell signaling and immune responses.
A: Myelodysplastic syndrome (MDS) is a disease affecting hematopoietic stem cells, leading to abnormal bone marrow function. The Human CD33 Stable Cell Line - CHO-K1 can simulate abnormal myeloid cell development, helping researchers identify molecular changes associated with MDS. This cell line can be used to screen drugs that may affect CD33 expression and function, providing potential targets for MDS treatment.
A: Myeloid leukemia is a cancer originating from myeloid cells. The Human CD33 Stable Cell Line - CHO-K1 can be used to study the role of CD33 in leukemia cells and how targeting CD33 can inhibit the growth and spread of leukemia cells. This cell line can serve as a model for drug screening and evaluation, aiding in the development of new leukemia treatments.
A: CD33 plays a crucial role in immune regulation, particularly in the activation and function of myeloid cells. The Human CD33 Stable Cell Line - CHO-K1 can provide a platform to study its regulatory role in immune responses. This helps reveal how CD33 affects inflammatory responses and the activation state of immune cells.
A: The Human CD33 Stable Cell Line - CHO-K1 can be used to evaluate the pharmacodynamic properties of antibody drugs targeting CD33. This cell line can simulate CD33 expression on human cells, helping researchers understand how these drugs bind to CD33 and assess their impact on cell function, which is crucial for drug development and clinical application.
A: Myeloid cells in the tumor microenvironment, including macrophages and dendritic cells, can interact with tumor cells through CD33. The Human CD33 Stable Cell Line - CHO-K1 can simulate these interactions, helping researchers understand the role of CD33 in tumor immune evasion and regulation of the tumor microenvironment. This is significant for developing new cancer immunotherapies.
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