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Cat.No. : CSC-RO1028 Host Cell: CHO-S
| Cat. No. | CSC-RO1028 |
| Description | CHO-S-BTLA cell line is engineered to stably overexpress human BTLA. |
| Gene | BTLA |
| Gene Species | Homo sapiens (Human) |
| Host Cell | CHO-S |
| Host Cell Species | Cricetulus griseus (Chinese hamster) |
| Stability | Validated for at least 10 passages |
| Application | 1. Studying the interactions between immune cells and cancer cells 2. Studying the mechanisms of resistance to immune checkpoint blockade 3. High-throughput screening 4. Drug target validation |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
A: The cell line was established by stably transfecting the human BTLA (B and T lymphocyte attenuator) gene into CHO-S cells.
A: This cell line can be used to study the role of BTLA in immune checkpoint therapies, especially in regulating immune responses and cancer treatment.
A: It is important to consider the drug's impact on BTLA expression and function, while ensuring that the screening conditions do not lead to nonspecific cellular responses.
A: Since BTLA is closely related to immune tolerance, this cell line is significant for understanding and modulating immune tolerance mechanisms.
A: The cells should be cultured in a specific medium containing selective antibiotics and regularly checked for BTLA protein expression and functionality.
A: It can be used to study the cell signaling pathways mediated by BTLA, especially in the activation and inhibition of immune cells.
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