Human B2M-FCGRT Stable Cell Line - CHO-K1

Name: Human B2M-FCGRT Stable Cell Line - CHO-K1
SKU: CSC-RO0510
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RO0510

Host Cell : CHO-K1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Cat. No.	CSC-RO0510
Description	This cell line is derived from CHO-K1 and is engineered to stably overexpress Human B2M and FCGRT.
Target Gene	B2M-FCGRT
Gene Species	Homo sapiens (Human)
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Studying the interactions between immune cells and cancer cells 2. Studying the mechanisms of resistance to immune checkpoint blockade 3. High-throughput screening 4. Drug target validation
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival

Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

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Q & A

Customer Reviews

Customer Q&As

What is the potential application of Human B2M-FCGRT Stable Cell Line - CHO-K1 in immune regulation research?

A: Human B2M-FCGRT Stable Cell Line - CHO-K1, stably expressing human beta-2-microglobulin (B2M) and neonatal Fc receptor transport protein (FCGRT), has significant potential in immune regulation research. B2M and FCGRT play crucial roles in the immune system, and this cell line can be used to study their functions in immune responses, antibody transport, and cell-mediated immunity.

How can the interaction and biological functions of B2M and FCGRT be studied using Human B2M-FCGRT Stable Cell Line - CHO-K1?

A: By using Human B2M-FCGRT Stable Cell Line - CHO-K1, co-immunoprecipitation experiments can be conducted to study direct or indirect interactions between B2M and FCGRT. Furthermore, knocking out one of the proteins using RNA interference or CRISPR/Cas9 technology can further explore the independent and synergistic actions of these two proteins in the cell.

What role does Human B2M-FCGRT Stable Cell Line - CHO-K1 play in drug screening and evaluation?

A: Human B2M-FCGRT Stable Cell Line - CHO-K1 can be used for drug screening, especially for evaluating compounds that affect immune regulation and antibody transport. This cell line can screen for small molecule drugs that affect the expression or function of B2M and FCGRT, providing new drug candidates for the treatment of immune diseases or immune-related disorders.

What is the potential application of Human B2M-FCGRT Stable Cell Line - CHO-K1 in studying autoimmune diseases?

A: Due to the importance of B2M and FCGRT in regulating immune responses, the Human B2M-FCGRT Stable Cell Line - CHO-K1 has potential applications in the study of autoimmune diseases. This cell line can be used to investigate the role of B2M and FCGRT in autoimmune diseases, particularly in terms of antibody-mediated immune responses and abnormalities in cell-mediated immune functions.

What are the key considerations when conducting gene editing experiments with Human B2M-FCGRT Stable Cell Line - CHO-K1?

A: When conducting gene editing experiments using the Human B2M-FCGRT Stable Cell Line - CHO-K1, it is crucial to ensure the specificity and efficiency of the editing tools to avoid off-target editing. Additionally, detailed gene expression and protein function analyses should be performed to verify the effects of gene editing and to monitor possible changes in cell phenotype.

What are the prospects of the Human B2M-FCGRT Stable Cell Line - CHO-K1 in cell therapy research?

A: The Human B2M-FCGRT Stable Cell Line - CHO-K1 shows promising prospects in cell therapy research. Especially in the development of cell therapies for immune-mediated diseases, this cell line can be used to evaluate the immunomodulatory effects of potential therapies, as well as their roles in antibody transport and presentation in cell therapy.

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