Transfected Stable Cell Lines
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Precision reporter, kinase, immune receptor, biosimilar, Cas9, and knockout stable cell lines for diverse applications.
Cat. No. : PTAK-011
| Cat. No. | PTAK-011 |
| Description | The Caspase-10 Activity Assay Kit (Fluorometric) is used for detecting the activity of caspases that recognize the sequence AEVD using fluorometric method. The assay is based on detection of cleavage of substrate AEVD-AFC (AFC:7-amino-4- trifluoromethyl coumarin). |
| Component |
•active caspase-10 •caspase-10 assay buffer •caspase-10 substrate (AEVD-AFC) •DTT •caspase-10 inhibitor (Z-VAD-FMK) •Microtiter plate |
| Applications | Useful for assaying the activity of caspase-10 |
| Size | 100 assays |
| Method | Fluorescence |
| Caution | Avoid freeze/thaw cycles |
A: Caspase-10 is an enzyme that, in humans, is encoded by the CASP10 gene. It plays a crucial role in programmed cell death, or apoptosis.
A: Caspase-10 functions as an initiator caspase within the extrinsic apoptosis pathway. Activated caspase-10 cleaves and activates downstream effector caspases, such as caspase-3, -6, and -7, leading to the execution of apoptosis.
A: Mutations or dysregulation of caspase-10 can contribute to various diseases, including autoimmune disorders, immunodeficiencies, and cancer.
A: Alterations in caspase-10 expression levels or activity can promote tumor growth and resistance to apoptosis, contributing to cancer progression.
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