BACE Activity Assay Kit

Name: BACE Activity Assay Kit
SKU: PTAK-001

For research use only. Not intended for any clinical use.

Cat.No.

PTAK-001

Description

The BACE1 Activity Assay Kit is designed to measure BACE1 activity for screening and profiling applications based on fluorescence resonance energy transfer (FRET) using a labeled peptide substrate.

Applications

Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.

Caution

Avoid freeze/thaw cycles

Component

•BACE1
•BACE assay buffer
•BACE1 FRET peptide substrate
•96-well plate

Method

FRET

Size/Form

100 assays

Publications

Q & A

Customer Reviews

Customer Q&As

What is BACE1?

A: BACE1 is an enzyme that is involved in the production and clearance of beta-amyloid peptides, which are the main components of amyloid plaques found in the brains of individuals with Alzheimer's disease.

What does the BACE1 enzyme do?

A: BACE1 cleaves amyloid precursor protein (APP) at a specific site, resulting in the formation of beta-amyloid peptides.

What is the role of BACE1 in Alzheimer's disease?

A: BACE1 plays a crucial role in the development of Alzheimer's disease. It is an enzyme responsible for cleaving amyloid precursor protein (APP) and releasing beta-amyloid (Aβ) peptides. The production and accumulation of Aβ peptides in the brain leads to the formation of amyloid plaques, which are a hallmark characteristic of Alzheimer's disease.

What does a BACE1 inhibitor do?

A: β-Site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors are potential disease-modifying drugs for the treatment of Alzheimer's disease (AD) because they prevent the production of synaptotoxic amyloid-β (Aβ).

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