Mouse P53 ORF clone(NM_011640.3)

Name: Mouse P53 ORF clone(NM_011640.3)
SKU: CDCL185593
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCL185593

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Product Information

Gene Information

Cat. No.	CDCL185593
Description	ORF Clone of Mus musculus transformation related protein 53 DNA.
Product Type	ORF clone
Gene Abbr	P53
Species	Mouse
ORF Size	1173bp
Vector	pMD18-T
Warning	This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Storage	store at -20°C

Target Gene

P53

Background

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

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