TP53 Validated sgRNA vector

Name: TP53 Validated sgRNA vector
SKU: SKO0058
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : SKO0058

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Product Information

Vector Map

Gene Information

Cat. No.	SKO0058
Description	Creative Biogene develops and optimizes genome editing technology to produce stable genome edited mammalian cell lines serving a wide-range of R&D activities in areas of basic research, diagnostic and therapeutic development. Our premade SuperKO sgRNA vectors are tailor-made to target many different genes respectively. We have successfully constructed a series of knockout cell lines using those sgRNAs.
Gene Abbr	TP53
Reporter	mCherry
Promoter	U6
Resistance	Amp
Selection	Ampicillin
Vector Type	Lentiviral Expression
Vector Length	7677 bp

Target Gene

TP53

Background

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

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