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Human NTSR1 Stable Cell Line-CHO

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Cat.No.
CSC-RG0902
Background
Neurotensin (NT) is a brain and gastrointestinal peptide that fulfills a dual function of neurotransmitter or neuromodulator in the nervous system and of local hormone in the periphery. NT is a neuromodulator of dopamine transmission and of anterior pituitary hormone secretion, and exerts potent hypothermic and analgesic effects in the brain. In the periphery, NT is a paracrine and endocrine modulator of the digestive tract and of the cardiovascular system of mammals and acts as a growth factor on a variety of normal or cancer cells. NT plays many central and peripheral functions through its interaction with specific receptors. Three subtypes of neurotensin receptors, NTSR1, NTSR2 and NTSR3, have been cloned so far. Among them, NTSR1 and NTSR2 belong to the family of G protein-coupled receptors and mediate the most known functions of NT, whereas the third neurotensin receptor’s function remains to be established.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Stability
12 passages of continuous culture (6 weeks) at 2 passages/week
Ship
Dry ice
Gene Information
Official Symbol
NTSR1
Synonyms
NTSR1; neurotensin receptor 1 (high affinity); neurotensin receptor type 1; NTR; NTR1; NTRH; NT-R-1; high-affinity levocabastine-insensitive neurotensin receptor;
Gene ID
MIM
UniProt ID
P30989
Chromosome Location
20q13
Pathway
Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem;
Function
G-protein coupled neurotensin receptor activity; G-protein coupled receptor activity; receptor activity; signal transducer activity;

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