Human NTSR1 Stable Cell Line-CHO-K1

Name: Human NTSR1 Stable Cell Line-CHO-K1
SKU: CSC-RG0902
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RG0902

Host Cell : CHO-K1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

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Cat. No.	CSC-RG0902
Target Gene	NTSR1
Gene Species	Homo sapiens (Human)
Abbr	CHO-HuNTSR1
Alias	NTSR1, NTR, NTR1, NTRH, NT-R-1
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Research on the mechanisms of GPCR-related diseases
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent
Morphology	Epithelial-like

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	NTSR1 neurotensin receptor 1 (high affinity) [ Homo sapiens ]
Gene Symbol	NTSR1
Synonyms	NTR
Gene Description	neurotensin receptor 1 (high affinity)
Gene ID	4923
Uni Prot ID	P30989
m RNA Refseq	NM_002531.2
Protein Refseq	NP_002522.2
Chromosome Location	20q13
Function	G-protein coupled neurotensin receptor activity; G-protein coupled receptor activity;
Pathway	Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem;
MIM	162651

CSC-RG0902-Human NTSR1 Stable Cell Line-CHO-K1-Datasheet

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Neurotensin (NT) is a brain and gastrointestinal peptide that fulfills a dual function of neurotransmitter or neuromodulator in the nervous system and of local hormone in the periphery. NT is a neuromodulator of dopamine transmission and of anterior pituitary hormone secretion, and exerts potent hypothermic and analgesic effects in the brain. In the periphery, NT is a paracrine and endocrine modulator of the digestive tract and of the cardiovascular system of mammals and acts as a growth factor on a variety of normal or cancer cells. NT plays many central and peripheral functions through its interaction with specific receptors. Three subtypes of neurotensin receptors, NTSR1, NTSR2 and NTSR3, have been cloned so far. Among them, NTSR1 and NTSR2 belong to the family of G protein-coupled receptors and mediate the most known functions of NT, whereas the third neurotensin receptor's function remains to be established.

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