Human KCND3 Stable Cell Line-HEK293

Name: Human KCND3 Stable Cell Line-HEK293
SKU: CSC-RI0141
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RI0141

Host Cell : HEK293 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RI0141
Description	This cell line is engineered to overexpress human KCND3.
Background	The human KCND3 gene encodes the pore-forming subunit of Kv4.3, a voltage-gated potassium channel. Kv4.3 channels expressed in heart are therapeutic targets in atrial fibrillation.
Target Gene	KCND3
Gene Species	Homo sapiens (Human)
Abbr	HEK293-HuKCND3
Alias	KCND3, KSHIVB, Kv4.3, KV4.3, KCND3L, KCND3S, MGC142035, MGC142037
Host Cell	HEK293
Host Cell Species	Homo sapiens (Human)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Channelopathies research
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Media Type	Cells were cultured in DMEM supplemented with 10% fetal bovine serum.
Growth Properties	Cells are cultured as a monolayer at 37°C in a humidified atmosphere with 5% CO₂. Split at 80-90% confluence, approximately 1:3-1:6.
Freeze Medium	Complete medium supplemented with 10% (v/v) DMSO
Morphology	Epithelial

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	KCND3 potassium voltage-gated channel, Shal-related subfamily, member 3 [ Homo sapiens ]
Gene Symbol	KCND3
Synonyms	KCND3; potassium voltage-gated channel, Shal-related subfamily, member 3; potassium voltage-gated channel subfamily D member 3; KSHIVB; Kv4.3; voltage-gated K+ channel; potassium ionic channel Kv4.3; sha1-related potassium channel Kv4.3; voltage-gated potassium channel subunit Kv4.3; KV4.3; KCND3L; KCND3S; MGC142035; MGC142037;
Gene ID	3752
Uni Prot ID	Q9UK17
m RNA Refseq	BC113477
Chromosome Location	1p13.2
Function	A-type (transient outward) potassium channel activity; metal ion binding; voltage-gated ion channel activity; voltage-gated potassium channel activity;
Pathway	Neuronal System, organism-specific biosystem; Potassium Channels, organism-specific biosystem; Voltage gated Potassium channels, organism-specific biosystem;
MIM	605411

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