Recombinant Human TNFRSF18 (C-Fc)

Name: Recombinant Human TNFRSF18 (C-Fc)
SKU: RP00585
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : RP00585 Tag : C-Fc

Expressed Region : Gln26-Gln161 Expression System : Human Cell

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Product Information

Gene Information

Cat. No.	RP00585
Description	Recombinant Human TNFRSF18 (C-Fc) is produced in our Human Cell expression system. The amino acid region expressed is Gln26-Gln161 with a Fc tag at the C terminus.
Species	Human
Tag	C-Fc
Mol Weight	41.2 KDa
Conjugate	Unconjugated
Format	Powder
Expressed Region	Gln26-Gln161
Expression System	Human Cell
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Purity	>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Endotoxin Level	< 1 EU/µg of protein by LAL method
Storage	Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles.
Shipping	The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.
Reconstitution	Always centrifuge tubes before opening. It is recommended to reconstitute the solution to a concentration above 100 μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Target Gene	TNFRSF18
Background	This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Synonyms	Tumor necrosis factor receptor superfamily member 18; TNFRSF18; Glucocorticoid-induced TNFR-related protein; CD357; TNFRSF18; AITR; GITR

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