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Motolimod

For research use only. Not intended for any clinical use.
Cat.No.
VAR-037
Description
Motolimod, also known as VTX-2337, is a selective TLR8 agonist that induces a response comparable with that of the receptor's natural ligand of viral single-stranded ribonucleic acid. In vitro studies have demonstrated that motolimod effectively activates TLR8, leading to enhanced NK-cell function, and in combination with cetuximab, increases tumor-directed ADCC.
Alias
VTX-2337
Product Type
Toll-like Receptor Agonists
Purity
≥98%
Storage
Store at -20°C in powder form. Store at -80°C once reconstituted.

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Q & A

Customer Reviews

Customer Q&As
How to store the reagent after receiving it?

A: The powder form of this reagent can be stored at -20°C, and after dissolution, it needs to be aliquoted and stored at -80°C.

What is the EC50 value of Motolimod?

A: The EC50 of Motolimod is about 100 nM, inducing the production of TNFα (EC50: 140 nM) and IL-12 (EC50: 120 nM) in PBMCs.

Can Motolimod act on TLR7 receptor?

A: No, Motolimod is a selective agonist of TLR8, which has at least 50 times higher selectivity for TLR8 than TLR7.

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Customer Reviews
ADCC

Motolimod in combination with cetuximab, increases tumor-directed ADCC.

United States

08/05/2022

Selective TLR8 agonist

The reagent Motolimod activates the TLR8 receptor and induces a response comparable to that of the receptor's natural ligand, viral single-stranded ribonucleic acid.

United States

03/15/2023

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