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Pam3CSK4

For research use only. Not intended for any clinical use.
Cat.No.
VAR-025
Description
Pam3CSK4 is a synthetic triacylated lipopeptide (LP) and a TLR2/TLR1 ligand. It is a potent activator of the pro-inflammatory transcription factor NF-kB. Pam3CSK4 has been proven to be a potent adjuvant for various vaccines, including a sublingual allergy vaccine, flu vaccine and leishmaniasis vaccine.
Alias
Pam3Cys-Ser-(Lys)4
Product Type
Toll-like Receptor Agonists
Storage
Store at -20°C

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Customer Q&As
How is Pam3CSK4 dissolved?

A: To improve its solubility, heat the test tube to 37°C and shake it briefly in an ultrasonic water bath. Different manufacturers and batches may have different solubilities, so the information is for reference only. If the required concentration exceeds the solubility limit of the product, please use a co-solvent or adjust the concentration accordingly. Solutions are generally not suitable for long-term storage; please use them as soon as possible.

What receptor is the Pam3CSK4 an agonist for?

A: Pam3CSK4 is an agonist for Toll-like receptor 1/2 (TLR1/TLR2), and it increases the tyrosine phosphorylation of PLCγ2 and the adapter protein LAT in a Syk and src-dependent manner. In addition, Pam3CSK4 induces platelet activation.

What are the characteristics of the Pam3CSK4?

A: The Pam3CSK4 is an effective activator of the LR2/TLR1 heterodimer and is a synthetic peptide without microbial contaminants.

Is the purity of the Pam3CSK4 reliable?

A: Reliable, each batch of the product has undergone high purity (≥95%) and functional testing.

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