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Loxoribine

For research use only. Not intended for any clinical use.
Cat.No.
VAR-046
Description
Loxoribine, also known as 7-Allyl-8-oxoguanosine and RWJ 21757, is a toll-like receptor 7 (TLR7) agonist. It is a potent immune stimulant with a relatively broad spectrum of immune biological activities including upregulation of the activity of B cells, T cells, NK cells and macrophages cells.
Alias
7-Allyl-8-oxoguanosine; RWJ 21757
Product Type
Toll-like Receptor Agonists
Purity
≥97%
Storage
Store at -20°C.

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Q & A

Customer Reviews

Customer Q&As
How to ensure that the prepared solution is sterile?

A: Loxoribine can be dissolved and sterilized by passing through a 0.22um filter membrane in a super-clean bench, but cannot be sterilized by high pressure.

Which cells can it act on?

A: Loxoribine has relatively broad immunobiological activity, including the activity of upregulating B cells, T cells, NK cells, and macrophages.

Can experimental animals take the reagent orally during use?

A: Yes, Loxoribine is an orally bioavailable and selective TLR7 agonist.

Is it better to buy the reagent in powder or solution form?

A: I personally think that buying powder is more convenient to use, and the concentration and solvent selection are more flexible.

What should be done if there is precipitation and separation during preparation?

A: It can be assisted in dissolution by heating and/or ultrasound.

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Customer Reviews
Broad spectrum

It can upregulate the activity of B cells, T cells, NK cells, and macrophages.

United States

01/12/2020

Antitumor and antiviral

The reagent has good antiviral and antitumor activities, and we have successfully used it in tumor-related research.

United States

04/11/2021

Good quality

We did not encounter any quality issues during storage and use, and the purity was high.

United States

11/21/2021

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