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Lipid A from S. minnesota R595

For research use only. Not intended for any clinical use.
Cat.No.
VAR-021
Description
Lipid A is a lipid component of an endotoxin held responsible for the toxicity of gram-negative bacteria. It is the innermost of the three regions of the lipopolysaccharide (LPS), also called endotoxin molecule, and its hydrophobic nature allows it to anchor the LPS to the outer membrane. Lipid A (and LPS) has been demonstrated to activate cells via Toll-like receptor 4 (TLR4), MD-2 and CD14 on the cell surface. They are being developed as drugs for the treatment of excessive inflammatory responses to infections with gram-negative bacteria.
Product Type
Bacteria-derived Adjuvant
Purity
≥99%
Stability
Stable for at least 2 years after receipt when stored at 4°C.
Storage
Store at 4°C;

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Customer Reviews

Customer Q&As
Does this reagent have inhibitory effects on both Gram-negative and Gram-positive bacteria?

A: No, the reagent is only toxic to gram-negative bacteria and does not have inhibitory effects on gram-positive bacteria.

Can it be used to treat Gram-negative bacterial infections?

A: No, the reagent is only for scientific research and cannot be used for other purposes.

What is the shelf life of this reagent usually?

A: The reagent can be stored at 4°C for at least 2 years.

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Customer Reviews
Acts on multiple receptors

Lipid A from S. minnesota R595 can activate cells through Toll-like receptor 4 (TLR4), MD-2, and CD14 on the cell surface.

United States

04/06/2023

Gram-negative bacteria

The reagent can be used in experiments related to gram-negative bacteria resistance, and is sometimes used as a positive control.

United States

05/05/2023

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