Human HLA-A2 Stable Cell Line - CFBE

Human stable cell line HLA-A2. The major histocompatibility complex class I (MHCI) molecules, which include the human leukocyte antigen-A2 (HLA-A2) gene, are expressed by CFBE through engineering. Anchored in the cell membrane, HLA-A2 is an essential component of the immune system that helps cytotoxic T cells deliver peptides produced from intracellular proteins and thereby trigger antigen-specific immune responses against cells that are infected or altered.

Eight exons make up the HLA-A gene, which is found on chromosome 6 and codes for the heavy chain of the MHCI molecule. Birdshot chorioretinopathy and severe cutaneous adverse responses are two conditions linked to the protein-coding gene HLA-A2. It contributes to immune surveillance and response by presenting a limited peptide repertoire made up of self-peptides, tumor peptide antigens, and viral epitopes. Adherent CFBE cells are commonly employed in research and are cultureable in vitro under conventional conditions. These cells have surface expression of HLA-A2, which makes it possible to analyze immunological responses and peptide presentation under controlled conditions.