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Cat.No. : CSC-RO0913 Host Cell: MC38
| Cat. No. | CSC-RO0913 |
| Description | This cell line is engineered to stably overexpress human FGL1. |
| Gene | FGL1 |
| Gene Species | Homo sapiens (Human) |
| Host Cell | MC38 |
| Host Cell Species | Mus musculus (Mouse) |
| Stability | Validated for at least 10 passages |
| Application | 1. Studying the interactions between immune cells and cancer cells 2. Studying the mechanisms of resistance to immune checkpoint blockade 3. High-throughput screening 4. Drug target validation |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
A: It was created by genetically modifying the mouse MC38 cell line using a lentiviral vector carrying the human FGL1 sequence, resulting in a stable MC38 clone expressing exogenous human FGL1.
A: Primarily used for drug screening and biological assays, especially in studying the interaction of FGL1 with the immune checkpoint molecule LAG3 and its effect on antigen-specific T cell activation.
A: It requires specific culture conditions, including RPMI1640 medium with puromycin and appropriate cell splitting ratios.
A: Its importance lies in studying the role of FGL1 in tumor immune evasion and immune checkpoint therapies due to FGL1's involvement in immune suppression.
A: Useful for assessing drugs targeting the FGL1 and LAG3 interaction and their impact on antigen-specific T cell activation.
A: Cells should be stored in liquid nitrogen and properly resuscitated and cultured prior to use, maintained under recommended conditions.
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