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Rat Fh cDNA Clone(NM_017005.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR011075

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Gene Information

Cat. No. CDFR011075
Description NativeORF clone of Rattus norvegicus fumarate hydratase 1 (Fh1) as transfection-ready DNA NM_017005.2
Product Type cDAN Clone
Gene Abbr Fh
Species Rat
Vector pCMV6Entry
Target Gene FH
Background The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy. [provided by RefSeq, Jul 2008]
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