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Mouse Ldlr ORF clone (NM_001252659.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCL151278

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Product Information

Gene Information

Cat. No. CDCL151278
Description Mus musculus low density lipoprotein receptor (Ldlr), transcript variant 3, mRNA.
Product Type ORF clone
Gene Abbr Ldlr
Species Mouse
ORF Size 2586bp
Format purified plasmid
Vector pDONR
Warning Please note that the protein for this clone has been annotated or predicted in the UNIPROT database to have a signal peptide. Placing a tag at the N-terminus of this protein may result in loss of the signal peptide function.
Target Gene LDLR
Background The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. The encoded protein is normally bound at the cell membrane, where it binds low density lipoprotein/cholesterol and is taken into the cell. Lysosomes release the cholesterol, which is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2022]
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